As GLP-1 medications like semaglutide and tirzepatide grow in popularity, many people are looking for safe, effective, over-the-counter (OTC) supplements that can support their results, ease side effects, and promote long-term well-being. And even if you’re not taking a GLP-1 medication, these same supplements can be incredibly helpful for anyone looking to support appetite control, digestive comfort, metabolic health, and overall nutrition. While no supplement can replace prescription GLP-1 therapy, the right ingredients can help support appetite control, digestive comfort, metabolic health, and essential nutrient intake.* Below is a guide to the best OTC GLP-1–friendly supplements, plus key ingredients to look for. What Do Over-the-Counter GLP-1 Supplements Do? The best OTC supplements for people using GLP-1 medications are those that support:* Appetite regulation Healthy inflammatory responses Blood sugar balance Digestive comfort Nutrient levels While formulas vary, the most supportive products often include ingredients like copaiba, xanthohumulone, prebiotic fiber (Sunfiber®, Solnul®), and specialized multivitamins tailored to those eating less or absorbing nutrients differently. Nutrients That Naturally Increase or Support GLP-1 Some nutrients and botanicals can help promote normal GLP-1 activity or work in conjunction with GLP-1 medications. 1. Copaiba (β-Caryophyllene) Copaiba is rich in β‑caryophyllene, a natural plant compound that may help support a healthy inflammatory response, maintain balanced blood sugar, and support fat metabolism.1,2,3 It has the potential to help your body feel more balanced and comfortable while using GLP-1 medications.* 2. Xanthohumulone Xanthohumulone is a natural compound found in hops studied for its effects on metabolism, appetite, and blood sugar balance. Research shows it may help your body release more GLP-1, use insulin more effectively, and reduce inflammation.4,5 Its antioxidant benefits make it a helpful option for supporting metabolic health, whether or not you’re using GLP-1 medications.* 3. Prebiotic Fiber (e.g., Partially Hydrolyzed Guar Gum, Resistant Starch) GLP-1 medications can slow digestion, which may lead to constipation or bloating.6 Prebiotic fibers help nourish healthy gut bacteria, support more regular bowel movements, and naturally encourage the production of short-chain fatty acids, which are compounds linked to supporting your body’s own GLP-1 release.7* They also support appetite control, fullness, and steady energy, all important during weight loss.* 4. Specialized Multivitamins for GLP-1 Users Many people eat significantly less on GLP-1 medications. Lower intake can quickly lead to vitamin and mineral gaps, especially for:8 Iron Calcium Magnesium Zinc Fat-soluble vitamins (A, D, E, K) B vitamins (B1 and B12) Vitamin C A multivitamin designed for GLP-1 users is recommended. These formulas are easier for your body to absorb, which is helpful when digestion is slower. How to Feel Your Best on GLP-1 Medications Taking GLP-1 medications can be life-changing, but side effects are common, especially digestive issues and low energy. The right supplement routine helps support overall well-being. 1. Use a Specialized Multivitamin Daily Because appetite may decrease significantly, a comprehensive multivitamin helps prevent: Weakness and fatigue Hair loss Brittle nails Mood changes Muscle loss Pick a multivitamin that’s easy for your body to absorb and made for smaller portions. 2. Add Prebiotic Fiber for Digestive and Metabolic Support* Fiber helps keep digestion regular, supports healthy gut bacteria, and promotes a feeling of fullness, all important during GLP-1 therapy.* 3. Consider Ingredients That Support GLP-1 Pathways Copaiba and xanthohumulone help support the body’s natural inflammation and metabolism, which may work alongside the benefits of GLP-1 medications. 4. Stay Hydrated and Prioritize Protein When digestion is reduced, protein intake can drop, which may slow metabolism. Try to get 60–90 grams of protein a day or more if your healthcare provider recommends it. 5. Monitor Blood Sugar and Energy Levels If you feel tired or notice low blood sugar, extra B vitamins or a specialized multivitamin can help keep your energy steady. Final Thoughts The best over-the-counter GLP-1 supplements support your whole body, including metabolism, digestion, inflammation, and nutrient absorption. Whether you want to support your weight loss results or simply feel your best while on GLP-1 medication, choosing the right ingredients can make a real difference.* Always talk with your healthcare provider before adding new supplements, especially if you’re taking prescription GLP-1 medications. Interested in learning more about GLP-1 medications? Check out these blogs: GLP-1 Medications: How They Support Weight Loss & Health GLP-1 Meal Plan: A Guide to Good Nutrition While Taking GLP-1 Medications GLP-1 Receptor Activation for Appetite Suppression References 1. Ames-Sibin AP et al. J Cell Biochem. 2018;119(12):10262-10277.2. Rodríguez-Mejía UU et al. Molecules. 2022;27(19):6156.3. Franco-Arroyo NN et al. J Med Food. 2022;25(10):993-1002.4. Gómez-Zorita S et al. Int J Mol Sci. 2024;25(22):12434.5. Bland JS et al. PharmaNutrition. 2015;3(2):46-52.6. Gorgojo-Martínez JJ et al. J Clin Med. 2022;12(1):145.7. Carlson JL et al. Curr Dev Nutr. 2018;2(3):nzy005.8. Mozaffarian D et al. 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